AN Associate Director Biostatistics

Internal link Associate Biostatistics ProQR Therapeutics
Posted on Jul 22, 2026
Our Development / Clinical Quantitative Science department is currently looking for an Associate Director Biostatistics (Full-time) to join our team.
Location: Leiden, the Netherlands (on-site).
The Role
As Associate Director Biostatistics, you will provide senior statistical leadership across clinical and translational programs. This is a hands-on, high-autonomy role with strong matrix leadership: you will shape quantitative strategy, guide study design and analysis, oversee complex computational work, and help teams make clear, evidence-based decisions.
You will work closely with Clinical Development, Clinical Operations, Data Management, Biomarkers, Regulatory, external partners, CROs, and senior stakeholders. The role requires critical thinking, scientific maturity, strong communication, and the ability to operate pragmatically in a fast-moving biotech environment.
What You Will Do -
Serve as biostatistical lead for clinical and translational projects, including protocol design, endpoints, estimands, sample size, SAPs, TLFs, interim/adaptive decisions, reporting, and regulatory responses. -
Develop and defend quantitative strategies using frequentist and Bayesian methods, simulation, leveraging external evidence, sensitivity analyses, and decision-focused interpretation. -
Plan, oversee, monitor, QC, and document demanding computational work, ensuring reproducibility, traceability, and fit-for-purpose quality. -
Contribute to clinical development strategy by translating biological, clinical, regulatory, and operational questions into robust statistical plans. -
Author and review statistical sections of protocols, synopses, briefing books, CSRs, regulatory documents, internal decision memos, and presentations. -
Oversee CROs, consultants, programmers, and analytical vendors to ensure timelines, quality, documentation, and audit readiness....